rotundus rhizome ethanolic extract in models of acute and chronic dermatitis. To investigate the topical anti-inflammatory activity of C.
MICHEL MOSO SKIN
In addition, it is commonly used in India, China and Japan in traditional medicine to treat different diseases, including dermatitis and other skin disorders. (Cyperaceae) is considered one of the most widely distributed plant species in the world, especially in tropical and subtropical regions. We hereby evidence the use of MOSO as a topical anti-inflammatory agent in inflammatory skin diseases, thus, expanding its therapeutic potential.Ĭyperus rotundus L. Both MOSO and OA depend on GC activation for anti-inflammatory effect but do not exhibit the same adverse effects seen in topical treatment with dexamethasone. OA is also effective in acute inflammation. The results suggest that MOSO is effective as a treatment for skin diseases that rely on keratinocyte hyperproliferation. Repeated administration of MOSO show a similar effect to dexamethasone on thymus weight, though MOSO did not present any influence on skin thickness, as well as in the weight of the spleen, adrenal gland and lymph node. Pre-treatment with GC antagonist mifepristone reversed the anti-inflammatory effect of MOSO and OA on the TPA model. Topical application of MOSO, but not OA, significantly reduced chronic skin inflammation and epidermal hypertrophy induced by multiple TPA applications. Neutrophil migration was also inhibited by treatment with MOSO. Only MOSO inhibited ear edema induced by AA. Topical application of MOSO and OA inhibited ear edema caused by TPA, and Phenol. Systemic activity and the influence of glucocorticoid receptors (GC) was also evaluated.
Acute and chronic inflammation was induced by applying 12-O-Tetradecanoylphorbol-13-acetate (TPA) and acute inflammation with either Arachidonic Acid (AA) or Phenol onto the ear of Swiss mice. The anti-inflammatory and anti-hyperproliferative effects of treatment with either MOSO or oleic acid (OA), its main constituent, was evaluated. MOSO was analyzed using gas chromatography/mass spectrometry. oleifera seed oil (MOSO) in animal models for inflammatory and hyperproliferative skin conditions. Our study aimed at investigating the effects of M. Popularly used in India and sub-Hymalaian region, Moringa oleifera (Moringaceae) is associated with healing properties demonstrated in its use as treatment of acute and chronic skin diseases. Therefore, our study demonstrated evidence for BdEO topical anti-inflammatory efficacy and safety, suggesting that it could be considered for developing of a new phytotherapeutic formulation as treatment for skin diseases. Taken together, the present results showed that the essential oil obtained by hydrodistillation from B. dracunculifolia leaf samples exhibit remarkable topical anti-inflammatory properties. Although BdEO appears to exert its anti-inflammatory effect through a corticosteroid pathway, no local or systemic side effects were observed. This protective effect was associated with reduced edema formation, smaller cellular influx into the inflamed tissue and reduction of keratinocytes hyperproliferation. In addition, topical treatment with BdEO inhibited inflammatory parameters in both acute and chronic models of skin inflammation.
Our results indicate that mainly terpenoids compounds compose BdEO. In addition, safety and a possible mechanism of action for BdEO essential oil were also investigated. Parameters such edema, cell migration and keratinocytes proliferation were evaluated. Topical anti-inflammatory activity of BdEO (0.1, 0.3 and 1.0 mg/ear) was evaluated in Arachidonic Acid or TPA-induced acute and chronic skin inflammation in mice. Materials and methodsīdEO was obtained from leaves and it was analyzed with Gas Chromatograph. The study aimed at evaluating the topical anti-inflammatory activity of B. dracunculifolia essential oil (BdEO) in mice models of acute and chronic skin inflammation. So far, only a few studies have investigated the B. dracunculifolia anti-inflammatory effect and none has investigated the effectiveness of essential oil on skin diseases.
Popularly it has been used as an immunostimulant, antibiotic, anti-inflammatory among other applications. Baccharis dracunculifolia (Asteraceae) is a commonly used plant in traditional medicine known as “alecrim-do-campo”.
0 kommentar(er)
